H2N2V1, Main, Exploration, bibRecord, 001F70

Relation between drug resistance and antigenicity among norakin-resistant mutants of influenza A (fowl plague) virus

Identifieur interne : 001F70 ( Main/Exploration ); précédent : 001F69; suivant : 001F71

Relation between drug resistance and antigenicity among norakin-resistant mutants of influenza A (fowl plague) virus

Auteurs : A. I. Klimov [Russie] ; S. G. Markushin [Russie] ; S. Prösch [Allemagne] ; V. P. Ginzburg [Russie] ; H. Heider [Allemagne] ; A. M. Heider [Russie] ; C. Schröeder [Allemagne] ; R. G. Webster [États-Unis]

Source :

Archives of Virology [ 0304-8608 ] ; 1992-03-01.

RBID : ISTEX:0D9675E47FC37B62387AF508383665FC9807AFE2

English descriptors

Teeft :
- Amantadine, Amino, Amino acid substitutions, Antigenic, Antigenic sites, Antigenic specificities, Antigenic specificity, Arch virol, Different positions, Drug resistance, Fowl, Fowl plague virus, Haemagglutinating, Haemagglutinating activity, Haemagglutinin, Heider, Influenza, Influenza virus, Monoclonal, Monoclonal antibodies, Monoclonal antibody, Mutant, Mutation, Norakin, Rimantadine, Substitution, Virol, Virus, Virus strains.

Abstract

Summary: Norakin-resistant (NR) mutants of fowl plague virus (A/FPV/Wey-bridge, H7N7) have 1 to 2 (in one instance 3) amino acid substitutions in different positions of the heavy (HA 1) and/or light (HA 2) subunits of the haemagglutinin (HA) molecule. Investigation of NR mutants using the haemagglutination inhibition test with monoclonal antibodies (MAb) to the HA of A/seal/Massachusetts/80 (H7N7) virus revealed that one of the mutants (NR 1) differs antigenically from the wild-type fowl plague virus: its haemagglutination was not inhibited by MAb 55/2 and 58/6. By contrast, MAb-resistant (escape) mutants, selected from the wild-type fowl plague virus under pressure from MAb 55/2 or 58/6, showed reduced drug sensitivity. These findings suggest a possibility of correlation between alteration of influenza virus antigenicity and change of its sensitivity to drugs whose target is the haemagglutinin. This potential effect should be taken into account when antiviral substances directed to surface influenza virus antigens are being developed for use as antiviral drugs.

Url:

https://api.istex.fr/ark:/67375/1BB-DDP844KG-0/fulltext.pdf

DOI: 10.1007/BF01314632

Affiliations:

Allemagne, Russie, États-Unis
Berlin, District fédéral central, Tennessee
Berlin, Moscou

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Summary: Norakin-resistant (NR) mutants of fowl plague virus (A/FPV/Wey-bridge, H7N7) have 1 to 2 (in one instance 3) amino acid substitutions in different positions of the heavy (HA 1) and/or light (HA 2) subunits of the haemagglutinin (HA) molecule. Investigation of NR mutants using the haemagglutination inhibition test with monoclonal antibodies (MAb) to the HA of A/seal/Massachusetts/80 (H7N7) virus revealed that one of the mutants (NR 1) differs antigenically from the wild-type fowl plague virus: its haemagglutination was not inhibited by MAb 55/2 and 58/6. By contrast, MAb-resistant (escape) mutants, selected from the wild-type fowl plague virus under pressure from MAb 55/2 or 58/6, showed reduced drug sensitivity. These findings suggest a possibility of correlation between alteration of influenza virus antigenicity and change of its sensitivity to drugs whose target is the haemagglutinin. This potential effect should be taken into account when antiviral substances directed to surface influenza virus antigens are being developed for use as antiviral drugs.</div>
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Relation between drug resistance and antigenicity among norakin-resistant mutants of influenza A (fowl plague) virus

Relation between drug resistance and antigenicity among norakin-resistant mutants of influenza A (fowl plague) virus

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri